Research – Page 5 – More Than A Dodo

If you could create an experiment to learn more about the human brain, what would you investigate? We posed this question in our Big Brain Competition last year, as part of the Brain Diaries exhibition with Oxford Neuroscience, and received a whopping 800 entries!

For the competition, Oxford University neuroscientists offered people the chance to use the state-of-the-art MRI scanner at Wellcome Centre For Integrative Neuroimaging at the John Radcliffe Hospital to investigate a burning question about the brain. We had ideas from the young and old, and by visitors from all around the world suggesting brilliant questions and some fascinating experiments.

Memory_fMRI — Functional MRI image of the human brain using the MRI Scanner

To judge all the ideas, entries were split into categories: feasible experiments, unfeasible experiments, under 18s, and questions about the brain. WIN researchers compiled a long-list for each, which was ranked by a panel of neuroscientists and people from the museum to reach the eventual winners.

Sadly, only one experiment could be carried out, so an overall winner was picked from the ‘feasible experiments’ category. The winning experiment was suggested by Richard Harrow, who wanted to understand how the brain identifies voices.

A person is put in the MRI scanner with headphones on. They are shown a photo of a person familiar to them, either a friend, family member or celebrity. Then, in their headphones they are played the voice of a person, but the voice is either sped up or slowed down.
They are required to say whether the face on the photo matches the voice they have heard. What happens in the brain when this confusion of audio and visual information is occurring? Will the brain find a way to identify the vocal signature of the voice, even if distorted, and be able to say with conviction if the photo and the voice are a match?
– Richard Harrow, winning competition idea

IMG_4498 (2) — Competition winner Richard Harrow was interviewed alongside neuroscientist Dr Stuart Clare during the live streaming of the experiment

On the day of the experiment, the winners and runners-up headed over to the WIN Centre to watch Richard’s winning experiment being conducted. The experiment was streamed live by Oxford Sparks and we had a clear result from the test, as neuroscientist Dr Holly Bridge explains:

The scans show that when you’re getting information that corresponds in both your auditory and your visual system you get a boost in your brain activity. We can detect that the brain does respond differently depending on whether or not you can match the face with the voice; it clearly has a lot to do with expectation.

Stuart and Holly — The brains behind the Big Brain Competition, Dr Holly Bridge and Dr Stuart Clare explained the results of the experiment on a Facebook Live stream

The scientists also wanted to answer as many of the other great brain questions as possible. So a series of articles picks out some of the broad themes in the competition ideas, including lifestyle, muscle memory and stress. Researchers also answered more big questions live on Facebook during this year’s Brain Awareness Week.

We sorted the many entries in the Big Brain Competition into themes such as vision, lifestyle, and language

Thank you to everyone who suggested an experiment or asked a question; it made for a fascinating conclusion to the Brain Diaries exhibition, and has definitely increased the amount of brain activity from staff across the Museum and Oxford Neuroscience… if only there was an MRI scanner for us to see it!

Winners of the Big Brain Competition at the Museum of Natural History with the neuroscientists. Left to right: James, Holly, Stuart, Misha, Richard, Lily, and Heidi

You can still get involved with the Big Brain Competition by trying the winning experiment at home.

20 October 201725 October 2017

Ellena GrilloLeave a comment

The crucial cortex

University of Oxford PhD student Lance Millar recently ran one of our Brain Spotlight events as part of the Brain Diaries exhibition programme. Here, Lance explains his research into neurodevelopmental disorders and possible treatments.

The brain has always been a fascinating organ for me. It is the site of our intelligence, our problem-solving and social skills, and it allows us to connect our senses to the world around us.

The large, folded outer part of the human brain is called the cortex, and is responsible for decision-making, language, face recognition, and a lot of the other things that I like to think are what make us human. The word cortex comes from the Greek for husk or outer shell, which underestimates the importance of what the cortex does.

Humans can survive with damage to the cortex, but depending on the part of the cortex that is damaged, a range of disabilities can result. People who have had a stroke can lose part of their cortex, leading to limb paralysis, loss of speech, or loss of memory, depending on the site of the damage.

B0009564 Human brain, coronal section, LM — *Cerebral cortex – Professor Michael R Peres – Wellcome Images*

Some people are also born with a developmental problem in the cortex, and are said to have a neurodevelopmental disorder. Such conditions are thought to include autism, schizophrenia, ADHD, and even dyslexia – all fairly common conditions. The damage to the cortex is subtle and complex in these conditions, and scientists are still working out exactly what happens to the brain during its prenatal development.

I am studying one particular neurodevelopmental disorder caused by lack of oxygen at birth. It is known to medical specialists as neonatal hypoxia ischaemia. The image on the right shows a cross-section MRI scan of a normal newborn human brain, alongside some babies who have been damaged by oxygen deprivation. You can see that the brains are smaller, the cortex is less folded and it takes up less space inside the skull.

MRI scans of normal newborn brains alongside those of babies who have been damaged by oxygen deprivation. Image: Woodward et al., New England Journal of Medicine, 2006

Scientists still don’t know how to protect the newborn brain from these injuries. Some are caused by inflammation which is a normal response to illness, but can wreak havoc in the confined space of the skull. Some is caused by the presence of free radicals, which are thought to contribute to ageing and organ failure, as the newborn brain doesn’t have many antioxidants to fight these chemicals. It’s also possible that the electrical signals that neurons within the brain send to each other contribute to the damage when there isn’t enough oxygen to feed them.

So what can we do to treat oxygen deprivation at birth? One breakthrough treatment currently available is known known as hypothermia. In this technique, the baby is cooled to 33℃ which slows down the brain-damaging chemical reactions which in turn protects the brain. This is currently the only treatment available, but I am involved in the study of possible alternatives.

We don’t want to introduce any drugs to the baby’s system as they might be harmful to normal development. So scientists are currently working on treatments which help the baby’s natural body proteins to protect the brain. I do this by looking at neurons under the microscope, and identifying proteins expressed by these neurons using fluorescent probes known as antibodies.

Neurons under the microscope — An example of neurons under the microscope. Image: Lancelot Millar

These neurons are expressing neuroserpin, a natural brain protein which decreases inflammation and cell death. I’m looking at exactly where neuroserpin is expressed in the brain, how it can be upregulated in response to oxygen deprivation, and how its chemical reactions could be used to protect the brain.

Another way to help people with neurodevelopmental disorders is to better understand how the cortex connects to other parts of the brain and how it can carry out complicated decisions. There is still so much to understand about the complexity of the human brain, and what seems like fundamental research could generate the springboard for new ideas for neurodevelopmental disorder treatments.

To explore the structure of the human brain and compare it to that of other animals see the Brain Diaries Brain Explorer below.

21 September 201728 September 2017

Ellena GrilloLeave a comment

All about Alzheimer’s

University of Toronto research fellow Jacqueline Zimmermann recently ran one of our Brain Spotlight events as part of the Brain Diaries exhibition programme. To mark World Alzheimer’s Day today, here Jacqueline tells us about the neurophysiology of Alzheimer’s disease and the risk factors we can actively reduce to lead happier, healthier, and longer lives.

Almost all of us have in some way been affected by Alzheimer’s disease, which makes the quest for a cure that much more personal. An estimated one in nine people over the age of 65 will develop the disease, and this risk also increases with age, according to the World Alzheimer’s Report in 2015.

Due to chemical toxins, and increased longevity, the incidence for Alzheimer’s disease is on the rise. But the good news is that there is a lot that you can do to reduce your risk. At the John Radcliffe Hospital in Oxford, hundreds of scientists are currently working towards identifying the cause and the solution to the disease.

At the Brain Spotlight event at the Museum I presented images of ageing brains, and explained how brains affected by Alzheimer’s have reduced volume in the temporal lobe and the hippocampus, regions critical for language and memory respectively. Diseased brains will also often show reduced frontal lobe volume, which may reflect the changes in personality and the ability to engage in planning which area associated with Alzheimer’s. The overall volume of the brain is also reduced in sufferers because cellular changes lead to the death of neurons.

Brain Atrophy in Alzheimer’s disease. Note: overall brain volume is reduced, hippocampal regions and frontal regions are particularly affected, and ventricles are enlarged. Image: http://www.lookfordiagnosis.com

Recently, a number of genes have been identified that are related to early onset Alzheimer’s, which is quite rare and much more hereditary than late-onset Alzheimer’s. At the Nuffield Department of Clinical Neurosciences, where I am a visiting researcher, we are investigating a late-onset Alzheimer’s risk gene called Apolipoprotein 4 (APOE4), looking at how it relates to subtle cognitive impairments in middle-aged people. Working with the Oxford Biobank we are trying to determine which cognitive assessments may be most effective in predicting these impairments.

Jacqueline Zimmerman — Functional brain imaging using electroencephalography at Rotman Research Institute in Toronto. Image: Rotman Research Institute

Although some of us may be more susceptible to Alzheimer’s than others, there are a number of environmental factors that contribute, including air pollution or additives in our food, like nitrogen-based chemicals which are used to preserve and flavour processed foods. It is important to reduce cholesterol in the diet, eat plenty of fruits and leafy greens, and engage in frequent physical and mental exercise.

Though there is speculation about the effectiveness of ‘brain games’ and how they translate into improvements in cognition in the real world, there are certainly large benefits of keeping your brain active.

1 September 20177 September 2017

Ellena GrilloLeave a comment

Amber time capsules

New Museum Research Fellow Dr. Ricardo Pérez-de la Fuente talks about his fascinating work with a special collection at the Museum of Comparative Zoology, Harvard University, and what he’ll be getting up to at the Museum of Natural History.

Amber, fossilised resin, has fascinated humanity since prehistoric times due to its mesmerising colour, shine, and fragrance when burned. From a scientific viewpoint however, what makes amber unique is the ability that the resin has to capture small portions of the ecosystem and the organisms living within almost instantaneously, in an unaltered way, preserving them for tens of millions of years. This has an unmatched fidelity among the fossiliferous materials.

Fibla_carpenteri_holotype_RPF_President_and_Fellows_of_Harvard_College — Holotype of *Fibla carpenteri* Engel, 1995, a snake-fly. Credit: President and Fellows of Harvard College.

During a four-year postdoctoral fellowship at the Museum of Comparative Zoology (MCZ) at Harvard University, I had the chance to curate, identify and digitise one of the premier fossil insect collections worldwide. It holds about 50,000–60,000 specimens, including around 10,000 amber inclusions. One of the unexpected outcomes of my time there was helping to rediscover a forgotten loan of about 400 Baltic amber samples that had been brought to the MCZ from the University of Königsberg during the 1930’s. This loan ended up sparing the specimens from being destroyed during the bombardment of the city of Königsberg (renamed Kaliningrad thereafter) in World War Two. The full-story as showcased by the Harvard Gazette can be found here.

Lagynodes_electriphilus_holotype_RPF_President_and_Fellows_of_Harvard_College — Holotype of *Lagynodes electriphilus* Brues, 1940, a megaspilid wasp. Credit: President and Fellows of Harvard College.

As a researcher specialising in fossil arthropods, one of the most remarkable challenges for me during the digitisation project at the MCZ was to overcome the thrill to learn more about the specimens that we were imaging. In what way were they different from their modern relatives? Were they perhaps new to science? What information were they providing from the ecosystem in which they lived? At present, I can fully embrace these questions and many more thanks to becoming a Museum Research Fellow at the Museum of Natural History.

Hypoponera_atavia_cotype_RPF_President_and_Fellows_of_Harvard_College — Cotype of *Hypoponera atavia* (Mayr, 1868), an ant. Credit: President and Fellows of Harvard College.

My research at the museum focuses on studying interactions between organisms in deep time and their behaviours, particularly in Cretaceous amber, such as plant-insect pollination relationships around 100 million years ago. During that time, a major shift was taking place in terrestrial ecosystems due to the diversification of angiosperms (flowering plants), which ended up replacing gymnosperms (non-flowering plants) as the dominant flora. There was also the appearance of key groups of organisms from the ecological perspective — ants and bees in the case of insects, for instance.

It is a well-accepted fact that preservation in amber is biased towards small organisms because the larger ones tend to escape the sticky resin more easily. But how easy it is for one to get lost in amber when examining its secrets and trying to unravel its mysteries! Becoming forever trapped within.

Some of the most remarkable Baltic amber specimens (about 40 million years old) returned to the Königsberg collection from the MCZ. Pictures: RPF. Credit: President and Fellows of Harvard College.

28 June 20173 July 2017

Ellena GrilloLeave a comment

The Big Brain Competition

What happens in your brain when you receive compliments? And what’s going on in your mind when you watch your football team win a match? Does the brain respond differently when recalling music, compared to listening to it? All these questions, and more, have been posed in our Big Brain Competition…

Coinciding with the Museum’s Brain Diaries exhibition, the Wellcome Centre for Integrative Neuroimaging is inviting you to ask your own question about the brain to be in with a chance to have it tested by neuroscientists using Oxford’s state-of-the art Magnetic Resonance Imaging (MRI) scanner.

The advanced MRI scanner at the John Radcliffe Hospital in Oxford is one of the strongest in the world. It allows scientists to carry out functional MRI (fMRI) scans to see the brain in action. This mind-blowing procedure can reveal how the brain changes when learning a new skill or how it compensates when someone recovers from brain damage. It can also reveal which areas are used when people speak, move or laugh, to give just a few examples.

This fMRI scan shows how blood flows to the visual cortex region at the back of the brain when viewing a visually-stimulating checkerboard pattern

layouttile — Dr Stuart Clare of the Nuffield Department of Clinical Neurosciences is asking you for questions about the brain

Functional MRI shows when a brain area is more active by detecting the changes in blood oxygen levels and blood flow that happen in response to neural activity. The technique can be used to produce activation maps showing which parts of the brain are involved in a particular mental process.

The scientist behind the Big Brain Competition is Dr Stuart Clare, whose research involves pushing the technological boundaries of the fMRI technique to reveal new insights about how the brain functions normally and how it is affected by disease. There is still so much that the fMRI scans can bring to light, so Stuart is asking you for ideas!

Over several years of inviting people in to see the beautiful pictures that our MRI scanner can produce, I’ve been fascinated by the questions they have about the brain and whether you can see this thing or that thing in our fMRI scans. With this competition we want to give people the unique access to our scanner and the chance to try an idea out for themselves.

When coming up with an idea for investigation there are a few practical things to bear in mind. Any activity has to be something people can do when lying down in the scanner and it has to be clear when they start and stop doing the activity. But Stuart is very open to ideas for experiments that they haven’t come across before – something that scientists really don’t already know the answer to.

The animation below explains how fMRI works and what it can do. So take a look, think up an experiment of your own and enter your idea via this form. The best one will be put into action by the research team and you will be able to watch the scans take place at the John Radcliffe Hospital yourself!

26 August 20168 September 2016

Ellena GrilloLeave a comment

On a dung beetle’s trail

Thanks to the work of our Head of Life Collections Darren Mann, and the Dung Beetle UK Mapping Project team, the conservation status of the UK’s dung beetles, chafers, and stag beetles (Scarabaeoidea) is currently undergoing a comprehensive review.

Contributing to this effort, Jack Davies, one of our summer interns, has been on the trail of a species that has proven to be particularly rare in the UK…

I am on the hunt for Aphodius lividus, a dung beetle with a truly cosmopolitan distribution, being found across most of the globe, but which is rather rare in Britain. Since 1990 it has been recorded at only six sites, though historical accounts suggest it was more common in the past.

Most of these historic records are from the south east of England, particularly Kent and the London area, but there are several geographically isolated records from across England and Wales too. So might A. lividus, whilst being extremely local, actually be widespread across the UK?

During my time at the Museum I have been contributing to a comprehensive review of this species’ distribution by helping to verify these records. This has involved a thorough search of collections, journals and the Museum archives, a process which revealed that many of the recordings of A. lividus were almost certainly erroneous.

We were able to discount the only two Welsh records, as well as single records from Cheshire, Leicestershire and Lincolnshire. Our reasons for doing so included a lack of supporting evidence, the unreliability of certain collectors, and the confirmed misidentifications of some specimens.

Jack Davies working on a collection of *Aphodius lividus*

The number of known localities for A. lividus decreased further when we realised that three of the reported sites in Kent most probably all refer to the same location. This is a common problem in this type of research, due to the very broad locality names found on Victorian specimen labels.

So it has become clear that this incredibly scarce beetle is even rarer than we first thought. But it’s not all bad news for A. lividus; our research has uncovered reports from localities in Devon and Northumberland in the old literature, which we found to be trustworthy records.

All the verified data from the project has been collated to produce this map of the distribution of A. lividus in the UK. Its very local distribution, and the very low number of recent records, confirm that this species should be classified as Vulnerable to Extinction in the UK.

Although it would be a shame to lose this species in Britain, we don’t believe it should be a priority for conservation efforts. Since Aphodius lividus has a strong preference for high temperatures, it’s likely that the UK is simply at the very edge of its range. It is also a very abundant species in many areas around the world, and it contributes little in terms of ecosystem services in Britain compared to many of our other dung beetles.

So conservation should instead aim to preserve the dung beetle ecosystem as whole, which supports a huge number of species and also brings many benefits to agriculture.

Tag: Research

The winning brainwave

The crucial cortex

All about Alzheimer’s

Amber time capsules

The Big Brain Competition

On a dung beetle’s trail